Researchers Find New Insights on Bacterial Viruses

UM researchers have published new insights in the journal Science on how bacteria cause infections, which may help with future infection treatments. Rather than studying bacteria, the researchers studied viruses that infect pathogenic bacteria, known as bacteriophages, as part of a National Institutes of Health grant to help develop a vaccine against bacterial infection.

“Bacteriophages are typically viewed as bacterial parasites,” says Patrick Secor, an assistant professor at UM and a co-author on the paper. “Because of the increasing prevalence of antibiotic-resistant bacteria, people are really getting interested in using bacteriophages (phage therapy) as an alternative to antibiotics to kill pathogenic bacteria.”

The bacteriophage used for therapy kill their bacterial hosts. Bacteriophages are diverse and considered the most prevalent biological entity on the planet.

When Secor and researchers at Stanford University looked for Pf bacteriophage in human wounds, they were surprised to find large numbers of the filamentous bacteriophage – an average of 1 million Pf bacteriophages per swab.

Secor and collaborators at Stanford University discovered that Pf bacteriophages are recognized as viruses by immune cells, and the same cell-surface receptors that recognize cold viruses also recognize bacteriophage.

The researchers believe this inappropriate immune response allows the bacteria to gain a foothold in wounds or lungs to establish an infection. The researchers hope their findings will spur new research into developing therapeutic strategies to treat bacterial infections through targeting bacteriophage.